Publishchemidea, 2022 No: 27
Submitted: Monday, December 19th, 2022
| Title of the idea: |
Trimethylorthoacetate as Acid activating reagent |
| Author of the idea: |
Ramesha |
| Email of the author |
ramesha63@hotmail.com |
| Key words for search: |
Carboxylicacid, Orthoester, amide |
| Explain briefly the idea |
Carboxylic acid on reacting with triethylorthoacetate, will form an interesting, very active intermediate. Which can react with any nucleophile to get respective product
|
| Why do you think this idea will work? |
Carboxylic acid group becomes very active |
| Do you have any experimental proof? |
No |
| Literature reference |
No |
| Where it is useful? |
In peptide synthesis and any other amide formation |
| Do you plan to work on this idea in near future? |
No |
| Interested in collaboration? |
No |
| Nature of idea: |
Both academic and Industrial |
| Youtube link: |
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